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Pharmacogenomics CYP2C9 and VKORC1 Polymorphisms The S-enantiomer of warfarin is mainly metabolized to 7-hydroxywarfarin by CYP2C9, a coumadin medication guide coumadin strengths side effects of coumadin blood thinner coumadin polymorphic enzyme .
The variant alleles, CYP2C9*2 and CYP2C9*3, result in decreased in coumadin vitro CYP2C9 enzymatic 7-hydroxylation of S-warfarin .
The frequencies of these alleles in Caucasians are approximately 11% and coumadin purpose what is the difference between warfarin and coumadin coumadin uses coumadin trade 7% for CYP2C9*2 and CYP2C9*3, respectively .
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