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Gram- negative bacteria: Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis Mechanism of Action: Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of cephalexin one or more penicillin-binding proteins and inhibiting cross- linking of the peptidoglycan structure .
The cephalosporins are cephalexin also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis .
does cephalexin have penicillin in it cephalexin syrup will cephalexin treat tooth infection can i 7mcg/ml; Half- life: 0 . 6hr ; Protein binding: 18-20%; Table 10 Adverse Effects: Hematologic: Neutropenia, leukopenia, is cephalexin good for a tooth infection cephalexin keflex side effects can cephalexin help with eosinophilia, thrombocytopenia, thrombocytosis, impaired platelet aggregation Dermatologic: Rash (maculopapular), puritis, urticaria Gastrointestinal: Diarrhea Hepatic: Abnormal liver function tests Renal: Interstitial nephitis Other: Anaphylaxis PO: 250mg, 500mg tablet or capsule 125mg/5ml, 250mg/5ml powder for reconstitution (suspension) 0 . 25-1g PO q6-12h Cystitis (uncomplicated): 500mg PO q12h Skin/skin structure infections: 500mg PO q12h Streptococcal pharyngitis: 500mg PO q12h Pediatric dose: 50-100mg/kg/day, divided q6-8h Otitis media: 75-100 mg/kg/day PO, divided q6h Disease state based dosing: Renal failure: CrCl 10-29ml/min administer usual dose q12-24h Hemodialysis: cephalexin Give normal dose after hemodialysis Hepatic failure: No dosing changes recommended at this time . Pharmacodynamics: Cephalosporins produce cephalexin time-dependent killing Pharmacokinetics: 500mg dose; Cmax: 20 .
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