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In addition, results for responder rates and exploratory efficacy analyses did not consistently tapentadol oxycodone nucynta not covered by insurance tapentadol y diabetes tapentadol reviews support efficacy of tapentadol SR .
It is notable when examining the efficacy results when analysed for baseline pain severity, the difference between tapentadol SR and placebo did not reach statistical tapentadol significance .
These results do not support use of tapentadol SR for treatment of severe chronic pain and for Study PAI-3009/KF12 did not achieve its primary efficacy endpoint tapentadol to demonstrate superiority of tapentadol SR over placebo in the change from baseline of the average pain intensity at Week 12 of the maintenance period or over the 12-week maintenance period using LOCF imputation .
Statistical significance was also not reached for the primary endpoint when tapentadol applying more conservative imputation methods, that is, BOCF, WOCF, modified BOCF and PMI .
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