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Plasma insulin levels in obese ZDF rats are higher than those in ZDF lean forxiga rats due to the increased insulin secretion for compensation for peripheral insulin resistance, but characteristically decline depending on the progression of hyperglycaemia (Finegood, et al .
Blood glucose (mean ± SE) at the start of treatment was 108 ± 5, 108 ± 4, and 98 ± 2 mg/dL in the dapagliflozin, control, and ZDF lean groups, forxiga dapagliflozin 10 mg forxiga canada invokana forxiga forxiga dapagliflozin side effects respectively .
Following administration of glucose 375 mg/kg, 25% glucose solution was infused so that the blood glucose level is maintained Blood glucose (mean ± SE) at the start of treatment was 133 ± 7, 135 ± 7, and forxiga 101 ± 2 mg/dL in the dapagliflozin, control, and ZDF lean groups, respectively .
ZDF rats, and no effects of dapagliflozin were observed on the forxiga pancreatic β-cell area .
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