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Plasma exposures (AUC) at the highest doses tested were 20 and 8 times that in humans at the maximum recommended human dose (MRHD) of 200 Sumatriptan was negative in in vitro (bacterial reverse mutation [Ames], gene cell mutation in Chinese hamster V79/HGPRT, chromosomal aberration in imitrex side effects high blood pressure sumatriptan injection device imitrex injection drug human lymphocytes) and in vivo (rat micronucleus) assays .
Impairment of Fertility When sumatriptan (5, 50, 500 mg/kg/day) was administered orally to male and female rats prior to and throughout the mating period, sumatriptan injection location sumatriptan injection vials sumatriptan injection sun pharma imitrex there was a treatment-related decrease in fertility secondary to a decrease in mating in animals treated with doses greater than 5 mg/kg/day (less than the MRHD on a mg/m2 basis) .
It is not sumatriptan injection ndc imitrex tabs imitrex dosage forms imitrex brand name imitrex dosage clear whether this finding was due to an effect on males or females or both .
When sumatriptan was administered by subcutaneous injection to male and female rats prior to and throughout the mating period, there was no evidence of impaired fertility at doses up to 60 Animal Toxicology and/or Pharmacology Corneal Opacities Dogs receiving oral sumatriptan imitrex developed corneal opacities and defects in the corneal epithelium .
Corneal opacities were seen at the lowest dose tested, sumatriptan injection needle-free delivery system imitrex with tylenol imitrex moa imitrex bluelight 2 mg/kg/day, and were present after 1 month of treatment .
Defects in the corneal epithelium were noted imitrex vs maxalt imitrex standard dose imitrex price comparison imitrex injection storage imitrex in a 60-week study .
Earlier examinations for these toxicities were not conducted and no-effect doses were imitrex not established .
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