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Induction of the microsomal drug metabolizing enzymes increased carisoprodol metabolism and shortened the duration of paralysis induced by carisoprodol; this induction of metabolizing enzymes may be related to the development of tolerance to carisoprodol with chronic exposure Carisoprodol is excreted in breast milk somacid at concentrations two to four times that in maternal plasma (34) .
Additionally, the carisoprodol somacid metabolite meprobamate is associated with an increased risk of congenital malformations during the first trimester of pregnancy (35) .
These results are in agreement with our results since fetal tissue of both groups (S1&S2) were highly affected than maternal somacid liver tissue .
Increased risk of developing concentration-dependent side effects even at normal somacid therapeutic doses of carisoprodol were determined by Dalen et al .
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