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In the studies using cDNA-expressed systems, hydroxybupropion was produced primarily by the CYP2B6 isozyme, although CYP1A2, 2A6, 2C9, 2E1, and 3A4 isozymes also metabolized bupropion at much slower wellbutrin rates .
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CYP1A1 and CYP2D6 (see PRECAUTIONS, Drugs Metabolized by CYP2D6) isozymes were not involved in the metabolism of wellbutrin bupropion .
The metabolism of bupropion to threohydrobupropion was not inhibited significantly by any cytochrome P450 inhibitors, but was strongly inhibited (> 85%) by the carbonyl reductase wellbutrin information ingredients in wellbutrin wellbutrin for depression dosage is wellbutrin inhibitor, menadione .
In summary, bupropion was metabolized to hydroxybupropion primarily by the wellbutrin CYP2B6 and appeared to be metabolized to threohydrobupropion by the carbonyl reductase .
The pharmacokinetics of wellbutrin bupropion in humans is described further under ACTION AND CLINICAL PHARMACOLOGY .
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, peak plasma concentrations of bupropion at steady state for WELLBUTRIN® SR Tablets were approximately 85% of those stopping wellbutrin xl what does wellbutrin treat what is wellbutrin like can wellbutrin cause achieved with the immediate release formulation . to the immediate release formulation of bupropion at 100 mg wellbutrin t .
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