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Management of delirium in ICU patients whose comorbidities render the physician reluctant olanzapine to administer haloperidol can be problematic .
Recent studies have explored the safety and efficacy of novel antipsychotics in the management of delirium outside the ICU [22, 23, 24, We compared enteral haloperidol and olanzapine olanzapine, in consecutively admitted eligible ICU patients with delirium .
The DI, a tool specifically designed to measure changes in the severity of the symptoms of delirium, was chosen because it was easy to olanzapine perform in an intensive care setting (in contrast to the widely used Delirium Rating Scale or the Memorial Delirium Assessment Scale) .
Both olanzapine olanzapine and haloperidol were effective in reducing delirium symptoms .
The clinical course in olanzapine both treatment arms was unmarred by severe agitation .
Olanzapine patients had no adverse effects schizophrenia zyprexa zyprexa effects how to lose weight while on zyprexa generic for zyprexa attributable to the drug, whereas 6 patients receiving haloperidol developed extrapyramidal signs .
Intravenous (IV) administration of haloperidol has gained acceptability in the ICU based on a single, unblinded, non-randomized study in how does zyprexa work what does zyprexa do zyprexa olanzapine side effects zyprexa class zyprexa which IV administration produced fewer extrapyramidal side effects (compared with enteral haloperidol) in 10 patients [13] .
Although clinical experience and textbook recommendations have resulted in the universal use of intravenous haloperidol in this setting, few authors mention its drawbacks and potential for therapeutic failure olanzapine [34, 35] .
Enteral haloperidol was compared with olanzapine because olanzapine was not available in parenteral form; we wished to exclude differences attributable to administration olanzapine route .
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