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Usage of cozaar:
cozaar About 14% of an orally-administered dose of losartan is converted to the active metabolite .
Mean peak concentrations of losartan and its active cozaar metabolite are reached in 1 hour and in 3-4 hours, respectively .
While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as losartan efectos secundarios disfuncion erectil losartan 50 mg equivalent to lisinopril losartan 100 that of losartan .
A meal slows absorption of losartan and decreases cozaar its Cmax but has only minor effects on losartan AUC or on the AUC of the metabolite (about 10% decreased) .
The pharmacokinetics of cozaar losartan and its active metabolite were also determined after IV doses of each component separately in healthy volunteers .
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