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Reducing the release of glutamate from the lyrica nerve cells in the brain is thought to help stabilise the electrical activity in the brain and prevent epileptic fits .
Pregabalin is used as an add-on treatment for adults whose epilepsy has not been lyrica well controlled by other anti-epileptic medicines .
It lyrica is used to prevent partial seizures, and partial seizures that spread to secondary generalised seizures .
Glutamate, substance P and noradrenaline are also involved in transmitting lyrica pain signals in the brain and nervous system .
As pregabalin reduces the release of these neurotransmitters it can also be used to treat nerve pain occuring as a result of damage to or a lyrica disturbance in the function of nerves (neuropathic pain) .
It can be used for peripheral neuropathic pain, ie nerve pain in the hands, lyrica legs or feet, or central neuropathic pain, eg as a result of a spinal cord injury .

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