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DRUG INTERACTIONS Inhibitors of Cytochrome P450 3A4 Fluticasone how long to use flonase flonase daily use does flonase make you sleepy how long should you use propionate is a substrate of CYP3A4 .
The use of flonase strong CYP3A4 inhibitors (e . , flonase ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin, conivaptan, lopinavir, nefazodone, voriconazole) with FLONASE Nasal Spray is not recommended because increased systemic corticosteroid adverse effects may A drug interaction trial with fluticasone propionate aqueous nasal spray in healthy subjects has shown that ritonavir (a strong CYP3A4 inhibitor) can significantly increase plasma fluticasone propionate exposure, resulting in significantly reduced serum cortisol concentrations [see Clinical Pharmacology (12 .
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