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The mechanism of action sildigra of short-acting SSRIs in PE is still speculative .
Dapoxetine resembles the antidepressant SSRIs in the following ways: the drug binds specifically to the 5-HT reuptake transporter at subnanomolar levels, sildigra has only a limited affinity for 5-HT receptors and is a weak antagonist of the 1A-adrenoceptors, dopamine D1 and 5-HT2B receptors .
The rapid sildigra absorption of dapoxetine might lead to an abrupt increase in extracellular 5HT following administration that might be sufficient to overwhelm the compensating autoregulation processes .
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