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Use Cautiously in: Patients at risk for bleeding (trauma, surgery, or other pathologic conditions); History of GI bleeding/ulcer disease; Severe hepatic impairment; Hypersensitivity to another thienopyridine (ticlopidine, prasugrel); OB: Use only if clearly indicated; Pedi: Safety and effectiveness plavix not established .
Therapeutic: antiplatelet agents Pharmacologic: platelet aggregation inhibitors Pregnancy Category B Adverse Reactions/Side Effects Reduction of atherosclerotic events (MI, stroke, vascular death) in patients at risk for such events including recent plavix and breastfeeding plavix blood pressure who makes plavix plavix and high blood pressure MI, acute coronary syndrome (unstable angina/non– Q-wave MI), stroke, or peripheral vascular disease .
Inhibits platelet aggregation by plavix and prilosec warning classification of plavix plavix and bruising pictures what is plavix irreversibly inhibiting the binding of ATP to platelet receptors .
Therapeutic Effects: Decreased occurrence of plavix atherosclerotic events in patients at risk .
Pharmacokinetics Absorption: Well absorbed following oral administration; rapidly metabolized to an active plavix and high blood pressure can plavix cause bleeding classification of plavix can you take antiplatelet compound .
Parent plavix price plavix blood in urine what is the generic name for plavix can you take ibuprofen with drug has no antiplatelet activity .
Protein Binding: Clopidogrel— 98%; active plavix metabolite— 94% .
Metabolism and Excretion: Rapidly and extensively converted by the liver (CYP2C19) to its active metabolite, which is then eliminated 50% in urine and 45% in feces; 2% of Whites, 4% of Blacks, and 14% of Asians have CYP2C19 genotype that results in reduced metabolism of clopidogrel (poor metabolizers) into its plavix active metabolite (may result inpantiplatelet effects) .
Half-life: 6 plavix hr (active metabolite 30 min) .
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