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In patients taking crestor coumarin anticoagulants and CRESTOR concomitantly, INR should be determined before starting CRESTOR and frequently enough during early therapy to ensure that no significant alteration of INR occurs [see WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY] .
The risk of skeletal muscle effects may be enhanced crestor when CRESTOR is used in combination with lipidmodifying doses ( ? 1 g/day) of niacin; caution should be used when prescribing with CRESTOR [see WARNINGS AND PRECAUTIONS] .
When CRESTOR was coadministered with fenofibrate, no clinically significant increase crestor in the AUC of rosuvastatin or fenofibrate was observed .
Because it is known that the risk of crestor myopathy during treatment with HMG-CoA reductase inhibitors is increased with concomitant use of fenofibrates, caution should be used when prescribing fenofibrates with CRESTOR [see WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY] .
Cases of myopathy, including rhabdomyolysis, have been reported with HMG-CoA reductase inhibitors, including crestor rosuvastatin, coadministered with colchicine, and caution should be exercised when prescribing CRESTOR with colchicine [see WARNINGS AND PRECAUTIONS] .
Cases of myopathy and rhabdomyolysis with acute renal failure crestor secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors , including CRESTOR .
These risks can occur at any crestor dose level, but are increased at the highest dose (40 mg) .
, age ? 65 years, inadequately treated hypothyroidism, patent expiration for crestor crestor risks is rosuvastatin calcium as good as crestor crestor and renal impairment) . CRESTOR should be prescribed with caution in patients with predisposing factors for crestor myopathy (e .
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