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The respiratory effects of sublingual buprenorphine solution (1, buprenorphine maintenance buprenorphine naloxone tablets buprenorphine qt buprenorphine dosage for 2, 4, 8, 16 or 32 mg) were compared to those of oral methadone (15, 30, 45 or 60 mg) in non-dependent, opioid experienced healthy male volunteers .
In this study, hypoventilation not requiring mechanical intervention was reported more frequently after buprenorphine sublingual solution doses of 4 mg and higher SUBOXONE® buprenorphine (buprenorphine and naloxone) Product Monograph (4 mg solution comparable approximately to a 6 mg tablet dose) than after methadone at these doses tested .
Both drugs decreased O 2 saturation to buprenorphine the same degree .
Effect of naloxone Naloxone had no clinically significant effect buprenorphine molecular weight buprenorphine lab test buprenorphine dea buprenorphine manufacturers when administered by the sublingual route; plasma concentrations are low and decline rapidly .
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