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5 Concomitant Use prevacid of PREVACID with Methotrexate Literature suggests that concomitant use of PPIs with methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate and prolong serum levels of methotrexate and/or its metabolite, possibly leading to methotrexate toxicities .
In high-dose methotrexate administration, a temporary withdrawal of the PPI may be prevacid considered in some patients [see Drug Interactions (7 . 3)] ADVERSE REACTIONS Worldwide, over 10,000 patients have been treated with prevacid PREVACID in Phase 2 or Phase 3 clinical trials involving various dosages and durations of treatment . 6) and Clinical Pharmacology mrsa zyvox zyvox interactions generic zyvox buy zyvox zyvox thrombocytopenia zyvox dosage zyvox (12 .
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Because clinical trials are conducted under widely varying conditions, prevacid adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice .
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